Happy Holidays to All. May your Christmas be filled with joy and
blessings and your New Year 'the very best of times'. For you all- thoughts on
darkness and light as we approach our darkest days- Dec. 20/21 in the Northern
Hemisphere. Blessings, Krispin
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Information on Melatonin testing is found at the end of the article. To
understand why I write the Newsletter scroll to the very bottom.
Krispin's Sporadic Newsletter- Komments on Nutrition and Health
Volume 1 Issue 1 December 2009
Thanks for being patient with all the 'opt-in' and respond emails.
I don't want to spam and as this is a brand new enterprise for me I am also
learning lots of new things about emails and html and web pages and spam filters
and sending more than 30 emails at a time, quite an experience that I hope will
benefit my clients and my non-client readers. Each topic I choose is because it
strikes me as really important and needing a deeper understanding. Especially
important to me in this newsletter are the implications of children under eight
and seniors not eating enough protein. This is a 'really big deal' and I hope
you will take it to heart and make sure the babes and elders in your life get
what they need.
What is Melatonin? Why Light, Darkness, and Sleep Matter.
The photo shows a compiled satellite picture of
darkest night worldwide. What is stunningly clear is that night isn't all that
dark for city dwellers in industrialized countries. Research demonstrates all
that 'night light' may not be good for us.
Healthy people produce adequate cycling
melatonin and base line melatonin. This is important because without core and
cycling melatonin, depression and disease flourish. The map of 'night light'
correlates with the incidence of cancers worldwide and higher incidences of
degenerative disorders. Our bodies need dark as well as light. What is suggested
in the research is the deregulated dark-light patterns found in developed
countries worldwide are contributing to increased incidence of disease.
If you have insufficient 24 hour gut, retinal,
or skin produced melatonin or too little or imbalanced cycling pineal melatonin
you need to change things, now. If you have a melatonin insufficiency or a
delayed sleep phase you will be more prone to depression, cancer, hypertension,
heart disease, obesity, metabolic disease, and even infection.>
One of the primary reasons melatonin is SO
important is because it regulates cell death. As we age or when we are injured
or exposed to toxins there may be a failure in 'apoptosis' which is how damaged
cells are induced to die. Melatonin has been shown to protect our healthy cells
from early demise while increasing 'death receptors' on damaged and/or malignant
cells resulting in improved treatments in cancer and though not yet clinically
verified, preventing replication of damaged DNA so we all stay healthier,
longer. Though specifics are yet to be explored, it is during the night, when
melatonin is produced in your pineal gland, some amazing processes occur
directing the removal of old, damaged cells while protecting healthy cells.
Getting rid of the old and damaged is critical to the survival all living
organisms. Good housekeeping makes a difference in cells too, and it looks very
much like cyclical pineal melatonin may be our essential 'house cleaner'.
Melatonin is a hormone, meaning a regulator of
cell birth, functioning, and death, altering cells by changes in receptors,
expression of enzymes, and other key elements of cellular regulation. Melatonin
is produced in your intestinal tract, your retinas, and your skin 24 hours a
day, and, in response to darkness, in your pineal gland. The healthy gut
produces 100 times more melatonin than the pineal gland.(1-12) In humans the
largest production of both melatonin and serotonin takes place in the healthy
functioning gastrointestinal tract. The function of gut, skin, and retinal
melatonin are primarily cell signaling while pineal melatonin acts in the
broader hormonal role especially that of regulating the production of DNA and
cleaning up 'debris'. All body production of melatonin depends on sufficient
supplies of l-tryptophan and pineal gland production also requires cycling DARK
and LIGHT. Adequate, high quality l-tryptophan containing protein is absolutely
necessary to produce serotonin and melatonin (and all other neurotransmitters)
throughout your body.
Regulation of your melatonin cycle (pineal
night-time production) requires dark when it is dark and light when it is light.
Artificial lighting (see picture) is strongly associated with impaired total
and/or cycle shifted melatonin and overall increases in cancer and other
IBS-D (Irritable Bowel Syndrome Diarrhea) is partially a result of actual loss
of melatonin producing cells in the gut with a relative imbalance of serotonin
resulting in cramping and uncontrollable bowel movements.(13-21)Other well
documented benefits of adequate base and cyclical melatonin include, antioxidant
protection of brain, heart, arteries, as well as protecting nuclear and
mitochondrial DNA. (22-31) Melatonin protects from cancer, including breast,
prostate, and colon;(32-45); allows improved attention and learning in children;
reduces anxiety and inappropriate anger at all ages;(46-53) Both your 24 hour
production in retina, skin and gut, and your night-time production from your
pineal gland are important to health.
Your brain and melatonin-
Your brain needs melatonin. While many are familiar with the
use of light for SAD (Seasonal Affective Disorder) you may be surprised to learn
melatonin's important role in all forms of depression. The clinical literature
shows both total melatonin and melatonin rhythm are critical to brain function
(memory and clarity of mind) and to sustain a good mood. We all recognize poor
sleep makes for a less productive day but impaired nighttime melatonin also
contributes to bipolar disease, Parkinson's Disease, and menstrual and menopause
associated mood disorders including foggy brain and anxiety AND even
Children and melatonin-
Melatonin and sleep disorders are also implicated as
problematic in children with ADD, ADHD and general learning disorders. (46-53) A
study in Japan found significantly lower levels of both serotonin and melatonin
in infants and children 8 years old and under if BREAKFAST did not contain
sufficient l-tryptophan containing protein. The children with insufficient
dietary protein, and thereby lowered serotonin and melatonin, suffered from
sleep phase disorders which has symptoms you will recognize- difficult to wake
up, easily frustrated and/or angered, difficulty learning, and difficulty going
to sleep. (80)
It is important to note the children in the
study from birth to eight years old suffered symptoms on the DAY of the morning
with insufficient protein. Each day's breakfast counted. As young infants and
children have extremely high protein needs for rapid growth breakfast, lunch,
and dinner must be protein sufficient. L-tryptophan is found in complete
proteins, meat, fish, milk, eggs (a particularly rich source), poultry, some
nuts and seeds, but never in large amounts (not even turkey) so both overall
quality and quantity count.
Seniors and melatonin-
Similarly seniors often have difficulty sleeping. A university study found
seniors 65 and older rarely got sufficient protein on a daily basis. In fact, on
the suggested dietary protein intake of 0.8 grams per kilo of body weight, 55
grams for a 150 pound person, 65 grams for a 180 pound persons, not one senior
remained in nitrogen balance (they lost more protein every day than they took
in). While this study did not look at l-tryptophan, it does suggest some of the
sleep issues in seniors may be related to low protein intakes. The researchers
did note the protein insufficiency contributed to weakening muscles and poor
energy which may keep them inside during daylight hours further disrupting
dark-light melatonin rhythm.
Make your own-
Before you take a drug or undergo a 'sleep study' consider improving your
protein, restoring your gut (see Practical Nutrition Workbook), getting some
sunlight during the day and keeping it dark at night. Exercise and daylight
exposure are both important factors for melatonin production and balance
(outdoor exercise please) as well as keeping things dark at night. We don't need
to TAKE melatonin. We need to make sure our guts are healthy AND sleep in the
dark (very dark, use light blocking curtains if necessary) and wake in the
light, very bright (don't wear sunglasses outside all the time). If you must
stay up late use special blue blocking lights and sunglasses so that your
melatonin rhythm is not disrupted.
you are a shift worker you need to get extra help. Find a book or work with
someone who understands how to mimic natural day and night. It will prolong your
life and help you avoid depression and immune problems and perhaps even some
types of cancer and degenerative diseases.
Darkness and Light-
Darkness AND light equate to pineal (cyclical) production of melatonin. The
brighter and then darker it is, the more melatonin produced by your pineal
gland. Aids to darkness include light blocking shades or curtains, and/or blue
blocking sunglasses or lights in the rooms where you spend your night-time
hours. Blue blocking lights or filters block the band/s of light that suppress
pineal melatonin production. Darkness in the daylight hours may deregulate your
melatonin cycle as may bright light at night. We are born for certain rhythms,
in this case darkness and light, which improve quality of waking and sleeping
and both quantity and quality of life.
Melatonin and kidney disease, cancer, or
While I don't believe healthy persons
need to supplement melatonin, in persons with kidney disease on dialysis
there is a failure of melatonin regulation. The cause is not yet known but
these patients may benefit from melatonin supplementation. As there are many
abnormalities when on dialysis, working with a clinical nutritionist or
other health care practitioner experienced in use of supplements in kidney
disease, is critical. This is not a do it yourself project. Cancer patients
may also benefit from melatonin supplementation during and after treatment
because their bodies may no longer regulate cyclical melatonin. As these are
very serious conditions make sure to work with someone who has both
knowledge and experience.
The other exception may be persons with
age-related macular degeneration (ARMD). Melatonin combined with zinc and
selenium has shown success in slowing or even reversing macular degeneration.
Melatonin ZN SE has been clinically shown to be effective. This strongly
suggests consuming adequate protein, zinc, and selenium AND maintaining your
light-dark cycle will contribute to avoiding macular degeneration, your best
The dose of melatonin used to slow and/or
reverse dry ARMD is 1-3 mg. nightly plus adequate zinc, 10-25 mg daily, and
selenium from foods or if not possible from supplements. When adding selenium
read labels. Excess or inorganic selenium is toxic. Never exceed 200 mcg daily
from all sources. The preferred form of selenium for eye protection is
selenomethione because this is the form shown to increase glutathione.
Selenomethionine also shows promise in protecting us from the damaging effects
of mercury exposure.
What you need to know AND follow are
the three keys to lifetime optimal melatonin production:
1. Adequate protein, a minimum of 1 gram for
each 2 pounds of body weight for adults and significantly more for infants,
children, and pregnant and nursing women. After 65, or when recovering from
injury, you need somewhat more than this.(81;82) AND for children eight and
under and infants do make sure breakfast is a PROTEIN meal. Cereal does not
count, not even high protein cereal.
2. Make sure you have optimal microbiota, your
"living shield' of good bacteria 100 trillion strong covering all your mucous
membranes. Having the 'right' microbes reverses all forms of bowel dysfunction,
restores gut integrity, repairs your immunity both innate and acquired and
restores the balance of serotonin and melatonin producing cells. The protocol is
in the latest edition of the workbook.
3. Get clear-cut, time appropriate, light-dark
exposure (daylight not 'lights' and darkness not 'lights') to regulate pineal
melatonin production. Get up, go out in the light. Go to bed at night. Establish
a healthy rhythm.
Though melatonin can be
purchased, respecting rhythms and cycles, and providing your body with all
essential elements to produce your own melatonin will benefit you in more ways
than a melatonin supplement ever could. Winter darkness produces more melatonin
in all of us. Enjoy the darkness. Know it as a time of regeneration and rebirth.
It is in the darkness clean-up, repair, healing, and renewal occur, preparing us
for new light, a new day, a new year. Happy New Year!
If you have increased your
l-tryptophan containing protein, gotten up in the morning and exposed yourself
to light, made a point to sleep in the darkness at a regular hour, and have
restored your healthy gut microbes (Gut Restoration Protocol), and still find
difficulty sleeping or waking consider a 24 hour melatonin test. 24 Hour
Melatonin Testing Available: Call or email (current clients only) to order a
(saliva) test kit. You'll pay me for postage ($5) and a phone appointment (cost
determined by time) after your results arrive. This is a saliva test, no blood
or lab visit needed. Your cost to the lab (sent with kit) will be $61.00
1-775-831-0292 or send me an email.
1. Bubenik GA. Thirty four years since the
discovery of gastrointestinal melatonin. J.Physiol Pharmacol. 2008 Aug;59 Suppl
The new edition, 12/2009, of the workbook,
Practical Nutrition, now has over 300 pages and contains information on how to
count and get sufficient protein and (brand new) information on how to restore
optimal gut and body microbes using high potency probiotics (400+ billion
multi-strain bacteria per dose) to ensure healthy melatonin and serotonin
production and improved immunity and longevity. It is currently on special $50
including shipping and extra copies or other items are just $25 each (max 2
extra items) when shipped with one order. Great for gifts. Order from
http://sunlightd.org/ If ordering for a Christmas present let me
know so that I send it 'fast'.
2. Konturek SJ, Konturek PC, Brzozowski T, Bubenik GA. Role of melatonin in
upper gastrointestinal tract. J.Physiol Pharmacol. 2007 Dec;58 Suppl 6:23-52.
3. Czesnikiewicz-Guzik M, Konturek SJ, Loster B, Wisniewska G, Majewski S.
Melatonin and its role in oxidative stress related diseases of oral cavity.
J.Physiol Pharmacol. 2007 Aug;58 Suppl 3:5-19.
4. Konturek SJ, Konturek PC, Brzozowska I, Pawlik M, Sliwowski Z,
Czesnikiewicz-Guzik M, Kwiecien S, Brzozowski T, Bubenik GA, Pawlik WW.
Localization and biological activities of melatonin in intact and diseased
gastrointestinal tract (GIT). J.Physiol Pharmacol. 2007 Sep;58(3):381-405.
5. Lepage O, Larson ET, Mayer I, Winberg S. Tryptophan affects both
gastrointestinal melatonin production and interrenal activity in stressed and
nonstressed rainbow trout. J.Pineal Res. 2005 May;38(4):264-71.
6. Bubenik GA. Localization, physiological significance and possible clinical
implication of gastrointestinal melatonin. Biol.Signals Recept. 2001
7. Bubenik GA, Hacker RR, Brown GM, Bartos L. Melatonin concentrations in the
luminal fluid, mucosa, and muscularis of the bovine and porcine gastrointestinal
tract. J.Pineal Res. 1999 Jan;26(1):56-63.
8. Anisimov VN, Kvetnoy IM, Chumakova NK, Kvetnaya TV, Molotkov AO, Pogudina NA,
Popovich IG, Popuchiev VV, Zabezhinski MA, Bartsch H, et al. Melatonin and colon
carcinogenesis. II. Intestinal melatonin-containing cells and serum melatonin
level in rats with 1,2-dimethylhydrazine-induced colon tumors.
Exp.Toxicol.Pathol. 1999 Jan;51(1):47-52.
9. Bubenik GA, Brown GM. Pinealectomy reduces melatonin levels in the serum but
not in the gastrointestinal tract of rats. Biol.Signals 1997 Jan;6(1):40-4.
10. Bubenik GA, Pang SF, Hacker RR, Smith PS. Melatonin concentrations in serum
and tissues of porcine gastrointestinal tract and their relationship to the
intake and passage of food. J.Pineal Res. 1996 Nov;21(4):251-6.
11. Bubenik GA, Pang SF. The role of serotonin and melatonin in gastrointestinal
physiology: ontogeny, regulation of food intake, and mutual serotonin-melatonin
feedback. J.Pineal Res. 1994 Mar;16(2):91-9.
12. Bubenik GA, Ball RO, Pang SF. The effect of food deprivation on brain and
gastrointestinal tissue levels of tryptophan, serotonin, 5-hydroxyindoleacetic
acid, and melatonin. J.Pineal Res. 1992 Jan;12(1):7-16.
13. Stepien A, Moskwa-Fortuna A, Wisniewska-Jarosinska M, Harasiuk A, Chojnacki
J. [Melatonin secretion and metabolism in patients with irritable bowel
syndrome]. Pol.Merkur Lekarski. 2009 May;26(155):440-3.
14. Lu WZ, Song GH, Gwee KA, Ho KY. The effects of melatonin on colonic transit
time in normal controls and IBS patients. Dig.Dis.Sci. 2009 May;54(5):1087-93.
15. Thor PJ, Krolczyk G, Gil K, Zurowski D, Nowak L. Melatonin and serotonin
effects on gastrointestinal motility. J.Physiol Pharmacol. 2007 Dec;58 Suppl
16. Osadchuk AM, Osadchuk MA, Kvetnoi IM. [Irritated bowel syndrome:
clinico-morphological types]. Klin.Med.(Mosk) 2007;85(3):46-50.
17. Komarov FI, Raikhlin NT, Rapoport SI, Malinovskaia NK, Voznesenskaia LA,
Rumiantseva AI. [Irritated bowel syndrome: clinicomorphological aspects of
treatment with melaxen]. Klin.Med.(Mosk) 2006;84(11):30-6.
18. Saha L, Malhotra S, Rana S, Bhasin D, Pandhi P. A preliminary study of
melatonin in irritable bowel syndrome. J.Clin.Gastroenterol. 2007
19. Lu WZ, Gwee KA, Moochhalla S, Ho KY. Melatonin improves bowel symptoms in
female patients with irritable bowel syndrome: a double-blind placebo-controlled
study. Aliment.Pharmacol.Ther. 2005 Nov 15;22(10):927-34.
20. Elsenbruch S. Melatonin: a novel treatment for IBS? Gut 2005
21. Song GH, Leng PH, Gwee KA, Moochhala SM, Ho KY. Melatonin improves abdominal
pain in irritable bowel syndrome patients who have sleep disturbances: a
randomised, double blind, placebo controlled study. Gut 2005 Oct;54(10):1402-7.
22. Petrosillo G, Colantuono G, Moro N, Ruggiero FM, Tiravanti E, Di VN, Fiore
T, Paradies G. Melatonin protects against heart ischemia-reperfusion injury by
inhibiting mitochondrial permeability transition pore opening. Am.J.Physiol
Heart Circ.Physiol 2009 Oct;297(4):H1487-H1493.
23. Cruz A, Tasset I, Ramirez LM, Arjona A, Segura J, Tunez I, Montilla P,
Muntane J, Padillo FJ. Effect of melatonin on
myocardial oxidative stress induced by experimental obstructive jaundice.
Rev.Esp.Enferm.Dig. 2009 Jul;101(7):460-3.
24. Ersahin M, Sehirli O, Toklu HZ, Suleymanoglu S, Emekli-Alturfan E, Yarat A,
Tatlidede E, Yegen BC, Sener G. Melatonin improves cardiovascular function and
ameliorates renal, cardiac and cerebral damage in rats with renovascular
hypertension. J.Pineal Res. 2009 Aug;47(1):97-106.
25. Saeidi M, Sobhani R, Movahedi M, Alsaeidi S, Samani RE. Effect of melatonin
in the prevention of postoperative pericardial adhesion formation.
Interact.Cardiovasc.Thorac.Surg. 2009 Jul;9(1):26-8.
26. Ismail SA, Mowafi HA. Melatonin provides anxiolysis, enhances analgesia,
decreases intraocular pressure, and promotes better operating conditions during
cataract surgery under topical anesthesia. Anesth.Analg. 2009
27. Zaslavskaia RM, Shcherban' EA, Logvinenko SI. [Melatonin in combined therapy
of patients with stable angina and arterial hypertension]. Klin.Med.(Mosk)
28. Genade S, Genis A, Ytrehus K, Huisamen B, Lochner A. Melatonin
receptor-mediated protection against myocardial ischaemia/reperfusion injury:
role of its anti-adrenergic actions. J.Pineal Res. 2008 Nov;45(4):449-58.
29. Merkur'eva GA, Ryzhak GA. [Effect of the pineal gland peptide preparation on
the diurnal profile of arterial pressure in middle-aged and elderly women with
ischemic heart disease and arterial hypertension]. Adv.Gerontol.
30. Yeung HM, Hung MW, Fung ML. Melatonin ameliorates calcium homeostasis in
myocardial and ischemia-reperfusion injury in chronically hypoxic rats. J.Pineal
Res. 2008 Nov;45(4):373-82.
31. Popov SS, Pashkov AN, Popova TN, Zoloedov VI, Semenikhina AB, Rakhmanova TI.
[Melatonin influence on free radical homeostasis in rat tissues at
thyrotoxicosis]. Biomed.Khim. 2008 Jan;54(1):114-21.
32. Hrushesky WJ, Grutsch JF, Wood P, Yang X, Oh EY, Ansell C, Kidder S, Ferrans
C, Quiton DF, Reynolds J, et al. Circadian Clock Manipulation for Cancer
Prevention and Control and the Relief of Cancer Symptoms. Integr.Cancer Ther.
2009 Nov 18.
33. Kantermann T, Roenneberg T. Is light-at-night a health risk factor or a
health risk predictor? Chronobiol.Int. 2009 Aug;26(6):1069-74.
34. Radogna F, Nuccitelli S, Mengoni F, Ghibelli L. Neuroprotection by melatonin
on astrocytoma cell death. Ann.N.Y.Acad.Sci. 2009 Aug;1171:509-13.
35. Joo SS, Yoo YM. Melatonin induces apoptotic death in LNCaP cells via p38 and
JNK pathways: therapeutic implications for prostate cancer. J.Pineal Res. 2009
36. Girgert R, Hanf V, Emons G, Grundker C. Membrane-bound melatonin receptor
MT1 down-regulates estrogen responsive genes in breast cancer cells. J.Pineal
Res. 2009 Aug;47(1):23-31.
37. Ozdemir F, Deniz O, Kaynar K, Arslan M, Kavgaci H, Yildiz B, Aydin F. The
effects of melatonin on human hepatoma (Hep G2) cell line. Bratisl.Lek.Listy
38. Zupancic D, Vidmar G, Jezernik K. Melatonin prevents the development of
hyperplastic urothelium induced by repeated doses of cyclophosphamide. Virchows
Arch. 2009 Jun;454(6):657-66.
39. itez-King G, Soto-Vega E, Ramirez-Rodriguez G. Melatonin modulates
microfilament phenotypes in epithelial cells: implications for adhesion and
inhibition of cancer cell migration. Histol.Histopathol. 2009 Jun;24(6):789-99.
40. Grant SG, Melan MA, Latimer JJ, Witt-Enderby PA. Melatonin and breast
cancer: cellular mechanisms, clinical studies and future perspectives.
41. Erren TC, Reiter RJ. A generalized theory of carcinogenesis due to
chronodisruption. Neuro.Endocrinol.Lett. 2008 Dec;29(6):815-21.
42. Blask DE. Melatonin, sleep disturbance and cancer risk. Sleep Med.Rev. 2009
43. Mirick DK, Davis S. Melatonin as a biomarker of circadian dysregulation.
Cancer Epidemiol.Biomarkers Prev. 2008 Dec;17(12):3306-13.
44. Cardinali DP, Esquifino AI, Srinivasan V, Pandi-Perumal SR. Melatonin and
the immune system in aging. Neuroimmunomodulation. 2008;15(4-6):272-8.
45. Tanaka T, Yasui Y, Tanaka M, Tanaka T, Oyama T, Rahman KM. Melatonin
suppresses AOM/DSS-induced large bowel oncogenesis in rats. Chem.Biol.Interact.
2009 Jan 27;177(2):128-36.
46. Reebye PN, Elbe D. The role of pharmacotherapy in the management of
self-regulation difficulties in young children. J.Can.Acad.Child
Adolesc.Psychiatry 2009 May;18(2):150-9.
47. Hoebert M, van der Heijden KB, van G, I, Smits MG. Long-term follow-up of
melatonin treatment in children with ADHD and chronic sleep onset insomnia.
J.Pineal Res. 2009 Aug;47(1):1-7.
48. Snowden S. Question 1. Does melatonin improve sleep pattern in children with
attention deficit hyperactivity disorder? Arch.Dis.Child 2009 Apr;94(4):321-2.
49. Pandi-Perumal SR, Srinivasan V, Spence DW, Cardinali DP. Role of the
melatonin system in the control of sleep: therapeutic implications. CNS.Drugs
50. Szeinberg A, Borodkin K, Dagan Y. Melatonin treatment in adolescents with
delayed sleep phase syndrome. Clin.Pediatr.(Phila) 2006 Nov;45(9):809-18.
51. Weiss MD, Wasdell MB, Bomben MM, Rea KJ, Freeman RD. Sleep hygiene and
melatonin treatment for children and adolescents with ADHD and initial
insomnia. J.Am.Acad.Child Adolesc.Psychiatry 2006 May;45(5):512-9.
52. Betancourt-Fursow de Jimenez YM, Jimenez-Leon JC, Jimenez-Betancourt CS.
[Attention deficit hyperactivity disorder and sleep disorders]. Rev.Neurol. 2006
Feb 13;42 Suppl 2:S37-S51.
53. Tjon Pian Gi CV, Broeren JP, Starreveld JS, Versteegh FG. Melatonin for
treatment of sleeping disorders in children with attention deficit/hyperactivity
disorder: a preliminary open label study. Eur.J.Pediatr. 2003
54. Ducrotte P. [Irritable bowel syndrome: dietary and pharmacological
therapeutic options]. Gastroenterol.Clin.Biol. 2009 Feb;33 Suppl 1:S68-S78.
55. Kalman J, Kalman S. [Depression as chronobiological illness].
Neuropsychopharmacol.Hung. 2009 Jun;11(2):69-81.
56. Nieuwenhuis RF, Spooren PF, Tilanus JJ. [Less need for insulin, a surprising
effect of phototherapy in insulin-dependent diabetes mellitus].
57. Kent ST, McClure LA, Crosson WL, Arnett DK, Wadley VG, Sathiakumar N. Effect
of sunlight exposure on cognitive function among depressed and non-depressed
participants: a REGARDS cross-sectional study. Environ.Health 2009;8:34.
58. Azorin JM, Kaladjian A. [Depression and circadian rhythm]. Encephale 2009
Jan;35 Suppl 2:S68-S71.
59. Ashkenazy T, Einat H, Kronfeld-Schor N. Effects of bright light treatment on
depression- and anxiety-like behaviors of diurnal rodents maintained on a short
daylight schedule. Behav.Brain Res. 2009 Aug 12;201(2):343-6.
60. Garzon C, Guerrero JM, Aramburu O, Guzman T. Effect of melatonin
administration on sleep, behavioral disorders and hypnotic drug discontinuation
in the elderly: a randomized, double-blind, placebo-controlled study. Aging
Clin.Exp.Res. 2009 Feb;21(1):38-42.
61. Srinivasan V, Pandi-Perumal SR, Trakht I, Spence DW, Hardeland R, Poeggeler
B, Cardinali DP. Pathophysiology of depression: role of sleep and the
melatonergic system. Psychiatry Res. 2009 Feb 28;165(3):201-14.
62. Willis GL. Parkinson's disease as a neuroendocrine disorder of circadian
function: dopamine-melatonin imbalance and the visual system in the genesis and
progression of the degenerative process. Rev.Neurosci. 2008;19(4-5):245-316.
63. Radeljak S, Zarkovic-Palijan T, Kovacevic D, Kovac M. Chromotherapy in the
regulation of neurohormonal balance in human brain--complementary application in
modern psychiatric treatment. Coll.Antropol. 2008 Oct;32 Suppl 2:185-8.
64. Kinrys G, Coleman E, Rothstein E. Natural remedies for anxiety disorders:
potential use and clinical applications. Depress.Anxiety. 2009;26(3):259-65.
65. Lam RW. Addressing circadian rhythm disturbances in depressed patients.
J.Psychopharmacol. 2008 Sep;22(7 Suppl):13-8.
66. Akpinar Z, Tokgoz S, Gokbel H, Okudan N, Uguz F, Yilmaz G. The association
of nocturnal serum melatonin levels with major depression in patients with acute
multiple sclerosis. Psychiatry Res. 2008 Nov 30;161(2):253-7.
67. Parry BL, Meliska CJ, Sorenson DL, Lopez AM, Martinez LF, Nowakowski S,
Elliott JA, Hauger RL, Kripke DF. Plasma melatonin circadian rhythm disturbances
during pregnancy and postpartum in depressed women and women with personal or
family histories of depression. Am.J.Psychiatry 2008 Dec;165(12):1551-8.
68. Carvalho LA, Gorenstein C, Moreno R, Pariante C, Markus RP. Effect of
antidepressants on melatonin metabolite in depressed patients.
J.Psychopharmacol. 2009 May;23(3):315-21.
69. Riemersma-van der Lek RF, Swaab DF, Twisk J, Hol EM, Hoogendijk WJ, Van
Someren EJ. Effect of bright light and melatonin on cognitive and noncognitive
function in elderly residents of group care facilities: a randomized controlled
trial. JAMA 2008 Jun 11;299(22):2642-55.
70. Lewy AJ. Melatonin and human chronobiology. Cold Spring
71. Hoang BX, Shaw DG, Pham PT, Levine SA. Neurobiological effects of melatonin
as related to cancer. Eur.J.Cancer Prev. 2007 Dec;16(6):511-6.
72. Vingradova IA, Iliukha VA, Fedorova AS, Khizhkin EA, Unzhakov AR, Iunash VD.
[Age-related changes of exercise capacity and some biochemical indices of rat
muscles under influence of different light conditions and pineal preparations].
73. Furio AM, Brusco LI, Cardinali DP. Possible therapeutic value of melatonin
in mild cognitive impairment: a retrospective study. J.Pineal Res. 2007
74. Phelps J. Dark therapy for bipolar disorder using amber lenses for blue
light blockade. Med.Hypotheses 2008;70(2):224-9.
75. Willis GL, Turner EJ. Primary and secondary features of Parkinson's disease
improve with strategic exposure to bright light: a case series study.
76. Barron ML. Light exposure, melatonin secretion, and menstrual cycle
parameters: an integrative review. Biol.Res.Nurs. 2007 Jul;9(1):49-69.
77. Eichling PS, Sahni J. Menopause related sleep disorders. J.Clin.Sleep Med.
2005 Jul 15;1(3):291-300.
78. Ravindra T, Lakshmi NK, Ahuja YR. Melatonin in pathogenesis and therapy of
cancer. Indian J.Med.Sci. 2006 Dec;60(12):523-35.
79. Morera AL, Abreu P. Seasonality of psychopathology and circannual melatonin
rhythm. J.Pineal Res. 2006 Oct;41(3):279-83.
80. Harada T, Hirotani M, Maeda M, Nomura H, Takeuchi H. Correlation between
breakfast tryptophan content and morning-evening in Japanese infants and
students aged 0-15 yrs. J.Physiol Anthropol. 2007 Mar;26(2):201-7.
81. Gaffney-Stomberg E, Insogna KL, Rodriguez NR, Kerstetter JE. Increasing
dietary protein requirements in elderly people for optimal muscle and bone
health. J.Am.Geriatr.Soc. 2009 Jun;57(6):1073-9.
82. Campbell WW, Trappe TA, Jozsi AC, Kruskall LJ, Wolfe RR, Evans WJ. Dietary
protein adequacy and lower body versus whole body resistive training in older
humans. J.Physiol 2002 Jul 15;542(Pt 2):631-42.
The Krispin's Sporadic Newsletter is my way of sharing with my clients and
friends the things I believe are truly important. I find the constant
'selling' of products, pills, potions, powders, for health and longevity to
be in direct opposition to my beliefs about how our bodies were meant to be.
There are 'basics', things we all need to eat to live long and healthy lives
and then there are the 'tweaks', things some of us may need and others may
not, BUT most of these 'things we need' will be found in FOOD. Our bodies
are designed to take the elements from our foods and work their magic,
transforming 'life from life'. Science seems, at times, to suggest taking
the latest 'element found' in a pill will help us all live to be 100+ yet
every centenarian alive today does not and did not take supplements.
The secrets of health
and longevity, while not yet all discovered, include eating whole real food that
is fresh and appropriate for your genetic heritage, exercising every day,
getting some sunlight every day, and surrendering daily to darkness for clean-up
and repair. Oh, and always, to the best of your ability, avoid people, places
and things known to be toxic. We can only handle so much 'junk' in a lifetime. I
look forward to writing again when time and topic dictate.